Gefitinib-based PROTAC 3

CAS No. 2230821-27-7

Gefitinib-based PROTAC 3 ( —— )

Catalog No. M13575 CAS No. 2230821-27-7

Gefitinib-based PROTAC 3 is a VHL-recruiting PROTAC that induces the degradation of EGFR and EGFR mutants with DC50 of 11.7 nM and 22.3 nM for HCC827 cell (Exon 19 del) and H3255 cell (L858R).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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2MG 58 In Stock
5MG 87 In Stock
10MG 160 In Stock
25MG 267 In Stock
50MG 408 In Stock
100MG 590 In Stock
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Biological Information

  • Product Name
    Gefitinib-based PROTAC 3
  • Note
    Research use only, not for human use.
  • Brief Description
    Gefitinib-based PROTAC 3 is a VHL-recruiting PROTAC that induces the degradation of EGFR and EGFR mutants with DC50 of 11.7 nM and 22.3 nM for HCC827 cell (Exon 19 del) and H3255 cell (L858R).
  • Description
    Gefitinib-based PROTAC 3 is a VHL-recruiting PROTAC that induces the degradation of EGFR and EGFR mutants with DC50 of 11.7 nM and 22.3 nM for HCC827 cell (Exon 19 del) and H3255 cell (L858R).
  • Synonyms
    ——
  • Pathway
    PROTACs
  • Target
    PROTAC
  • Recptor
    PROTAC
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2230821-27-7
  • Formula Weight
    934.52
  • Molecular Formula
    C47H57ClFN7O8S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 60 mg/mL64.20 mM
  • SMILES
    CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)CCOCCOCCCCCOC4=C(C=C5C(=C4)C(=NC=N5)NC6=CC(=C(C=C6)F)Cl)OC)O
  • Chemical Name
    (2S,4R)-1-((S)-2-(3-(2-((5-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)pentyl)oxy)ethoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Burslem GM, et al. Cell Chem Biol. 2018 Jan 18;25(1):67-77.e3.
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